Comparison of Drug Resistance pattern under supervised Vs unsupervised treatment of Tuberculosis

Background: The prevalence of drug resistance was higher in areas with poor tuberculosis control. Resistance to Anti tuberculosis treatment was found in all 35 countries and regions surveyed. Objective: To Compare of Drug Resistance pattern in cases under supervised vs unsupervised treatment. Study design: Hospital based study. Setting: Department of Pulmonary Medicine, Motilal Nehru Medical College (MLNMC), Allahabad, (U.P) India. Participants: 52 patients. Sampling: Purposive sampling method. Results: Out of 52 patients 23(44.23 %) were relapse, 22(42.30 %) were treatment failure and 7(13.46) were defaulter. Treatment failure cases were more in unsupervised group 28.84% compare with supervised group 13.46%, relapse were more in supervised group 26.9%, as compared to unsupervised group 17.3% and defaulter were more in unsupervised group 11.5%, as compare to supervised group 1.96%. nine patients (17.6%) who took supervised treatment previously were susceptible to all tested drug as compare to unsupervised group in which 3(5.9%) cases were susceptible to all tested drug. 6(11.76%) cases were single drug resistance in supervised group as compared to unsupervised in which 7(13.72%) cases were single drug resistance. Poly resistance were more 12 (23.53%) in unsupervised group as compare to supervised group in which 4(7.84%) cases were poly resistance. Multi drug resistance cases were more 7(7.84%) cases in unsupervised group as compare to supervised group in which 3(5.90%) cases were multi drug resistance Conclusion: It was concluded that supersized strategy was superior to unsupervised treatment in controlling the tuberculosis infection and in preventing the emergence of drug resistance tuberculosis Key-words: Multi drug resistance, Defaulter, Treatment failure, Relapse, supervised, unsupervised